Modulation of Antiviral Immunity by Heme Oxygenase-1.
Identifieur interne : 000A83 ( Main/Exploration ); précédent : 000A82; suivant : 000A84Modulation of Antiviral Immunity by Heme Oxygenase-1.
Auteurs : Janyra A. Espinoza [Chili] ; Pablo A. González [Chili] ; Alexis M. Kalergis [Chili]Source :
- The American journal of pathology [ 1525-2191 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Heme oxygenase-1, Hème.
- pharmacologie : Antiviraux.
- Animaux, Humains, Immunité, Modèles biologiques.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Heme, Heme Oxygenase-1.
- chemical , pharmacology : Antiviral Agents.
- drug effects : Immunity.
- Animals, Humans, Models, Biological.
Abstract
Heme oxygenase-1 (HO-1) is a stress-inducible, anti-inflammatory, and cytoprotective enzyme expressed in most cell types in the organism. Under several stress stimuli, HO-1 expression and activity is up-regulated to catalyze the rate-limiting enzymatic step of heme degradation into carbon monoxide, free iron, and biliverdin. Besides its effects on cell metabolism, HO-1 is also capable of modulating host innate and adaptive immune responses in response to sepsis, transplantation, and autoimmunity, and preventing oxidative damage associated with inflammation. In addition, recent studies have reported that HO-1 can exert a significant antiviral activity against a wide variety of viruses, including HIV, hepatitis C virus, hepatitis B virus, enterovirus 71, influenza virus, respiratory syncytial virus, dengue virus, and Ebola virus, among others. Herein, we address the current understanding of the functional significance of HO-1 against a variety of viruses and its potential as a therapeutic strategy to prevent and control viral infections. Furthermore, we review the most important features of the immunoregulatory functions for this enzyme.
DOI: 10.1016/j.ajpath.2016.11.011
PubMed: 28082120
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000327
- to stream PubMed, to step Curation: 000326
- to stream PubMed, to step Checkpoint: 000317
- to stream Ncbi, to step Merge: 000842
- to stream Ncbi, to step Curation: 000842
- to stream Ncbi, to step Checkpoint: 000842
- to stream Main, to step Merge: 000A84
- to stream Main, to step Curation: 000A83
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Modulation of Antiviral Immunity by Heme Oxygenase-1.</title><author><name sortKey="Espinoza, Janyra A" sort="Espinoza, Janyra A" uniqKey="Espinoza J" first="Janyra A" last="Espinoza">Janyra A. Espinoza</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics and Microbiology, Millennium Institute on Immunology and Immunotherapy, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, Millennium Institute on Immunology and Immunotherapy, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez, Pablo A" sort="Gonzalez, Pablo A" uniqKey="Gonzalez P" first="Pablo A" last="González">Pablo A. González</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics and Microbiology, Millennium Institute on Immunology and Immunotherapy, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, Millennium Institute on Immunology and Immunotherapy, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Kalergis, Alexis M" sort="Kalergis, Alexis M" uniqKey="Kalergis A" first="Alexis M" last="Kalergis">Alexis M. Kalergis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics and Microbiology, Millennium Institute on Immunology and Immunotherapy, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile; INSERM, Combined Research Unit 1064, Nantes University Hospital Nantes, Institute for Transplantation-Urology-Nephrology, Université de Nantes, Faculty of Medicine, Nantes, France; Department of Endocrinology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address: akalergis@bio.puc.cl.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, Millennium Institute on Immunology and Immunotherapy, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile; INSERM, Combined Research Unit 1064, Nantes University Hospital Nantes, Institute for Transplantation-Urology-Nephrology, Université de Nantes, Faculty of Medicine, Nantes, France; Department of Endocrinology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28082120</idno><idno type="pmid">28082120</idno><idno type="doi">10.1016/j.ajpath.2016.11.011</idno><idno type="wicri:Area/PubMed/Corpus">000327</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000327</idno><idno type="wicri:Area/PubMed/Curation">000326</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000326</idno><idno type="wicri:Area/PubMed/Checkpoint">000317</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000317</idno><idno type="wicri:Area/Ncbi/Merge">000842</idno><idno type="wicri:Area/Ncbi/Curation">000842</idno><idno type="wicri:Area/Ncbi/Checkpoint">000842</idno><idno type="wicri:Area/Main/Merge">000A84</idno><idno type="wicri:Area/Main/Curation">000A83</idno><idno type="wicri:Area/Main/Exploration">000A83</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Modulation of Antiviral Immunity by Heme Oxygenase-1.</title><author><name sortKey="Espinoza, Janyra A" sort="Espinoza, Janyra A" uniqKey="Espinoza J" first="Janyra A" last="Espinoza">Janyra A. Espinoza</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics and Microbiology, Millennium Institute on Immunology and Immunotherapy, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, Millennium Institute on Immunology and Immunotherapy, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez, Pablo A" sort="Gonzalez, Pablo A" uniqKey="Gonzalez P" first="Pablo A" last="González">Pablo A. González</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics and Microbiology, Millennium Institute on Immunology and Immunotherapy, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, Millennium Institute on Immunology and Immunotherapy, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Kalergis, Alexis M" sort="Kalergis, Alexis M" uniqKey="Kalergis A" first="Alexis M" last="Kalergis">Alexis M. Kalergis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics and Microbiology, Millennium Institute on Immunology and Immunotherapy, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile; INSERM, Combined Research Unit 1064, Nantes University Hospital Nantes, Institute for Transplantation-Urology-Nephrology, Université de Nantes, Faculty of Medicine, Nantes, France; Department of Endocrinology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address: akalergis@bio.puc.cl.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, Millennium Institute on Immunology and Immunotherapy, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile; INSERM, Combined Research Unit 1064, Nantes University Hospital Nantes, Institute for Transplantation-Urology-Nephrology, Université de Nantes, Faculty of Medicine, Nantes, France; Department of Endocrinology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author></analytic><series><title level="j">The American journal of pathology</title><idno type="eISSN">1525-2191</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Heme (metabolism)</term><term>Heme Oxygenase-1 (metabolism)</term><term>Humans</term><term>Immunity (drug effects)</term><term>Models, Biological</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Heme oxygenase-1 (métabolisme)</term><term>Humains</term><term>Hème (métabolisme)</term><term>Immunité ()</term><term>Modèles biologiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Heme</term><term>Heme Oxygenase-1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Immunity</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Heme oxygenase-1</term><term>Hème</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Models, Biological</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Immunité</term><term>Modèles biologiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Heme oxygenase-1 (HO-1) is a stress-inducible, anti-inflammatory, and cytoprotective enzyme expressed in most cell types in the organism. Under several stress stimuli, HO-1 expression and activity is up-regulated to catalyze the rate-limiting enzymatic step of heme degradation into carbon monoxide, free iron, and biliverdin. Besides its effects on cell metabolism, HO-1 is also capable of modulating host innate and adaptive immune responses in response to sepsis, transplantation, and autoimmunity, and preventing oxidative damage associated with inflammation. In addition, recent studies have reported that HO-1 can exert a significant antiviral activity against a wide variety of viruses, including HIV, hepatitis C virus, hepatitis B virus, enterovirus 71, influenza virus, respiratory syncytial virus, dengue virus, and Ebola virus, among others. Herein, we address the current understanding of the functional significance of HO-1 against a variety of viruses and its potential as a therapeutic strategy to prevent and control viral infections. Furthermore, we review the most important features of the immunoregulatory functions for this enzyme.</div></front></TEI><affiliations><list><country><li>Chili</li></country></list><tree><country name="Chili"><noRegion><name sortKey="Espinoza, Janyra A" sort="Espinoza, Janyra A" uniqKey="Espinoza J" first="Janyra A" last="Espinoza">Janyra A. Espinoza</name></noRegion><name sortKey="Gonzalez, Pablo A" sort="Gonzalez, Pablo A" uniqKey="Gonzalez P" first="Pablo A" last="González">Pablo A. González</name><name sortKey="Kalergis, Alexis M" sort="Kalergis, Alexis M" uniqKey="Kalergis A" first="Alexis M" last="Kalergis">Alexis M. Kalergis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A83 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A83 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:28082120
|texte= Modulation of Antiviral Immunity by Heme Oxygenase-1.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28082120" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a StressCovidV1
| This area was generated with Dilib version V0.6.33. |  |